A study from the European collaborative project miniNO has been published in the journal Science Translational Medicine and identifies minipuberty as a critical period for brain development.
This study was carried out in collaboration with Dr Konstantina Chachlaki and Prevot from INSERM, Dr. Laurent Storme from CHU Lille, Drs Pitteloud, Messina and Santoni from the Center Hospitalier Universitaire Vaudois – CHUV and Dr. Alan Carleton from the University of Geneva- UNIGE, partners of the miniNO project.
NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice.
Chachlaki K, Messina A, Delli V, Leysen V, Maurnyi C, Huber C, Ternier G, Skrapits K, Papadakis G, Shruti S, Kapanidou M, Cheng X, Acierno J, Rademaker J, Rasika S, Quinton R, Niedziela M, L’Allemand D, Pignatelli D, Dirlewander M, Lang-Muritano M, Kempf P, Catteau-Jonard S, Niederländer NJ, Ciofi P, Tena-Sempere M, Garthwaite J, Storme L, Avan P, Hrabovszky E, Carleton A, Santoni F, Giacobini P, Pitteloud N, Prevot V. Sci Transl Med. 2022 Oct 5;14(665):eabh2369.
doi:10.1126/scitranslmed.abh2369. PMID: 36197968
They speak about it:
- Article on Handicap.fr by Cassandre Roegeret (FR): available here
- Press release on Inserm website (FR & EN): available here
- Article on Science Eureka website (EN): available here